Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery
نویسندگان
چکیده
منابع مشابه
Carbopol-incorporated thermoreversible gel for intranasal drug delivery.
The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and d...
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Almost 40% of active Pharmaceutical ingredients have low oral bioavailability, high hepatic first-pass metabolism and also less efficient in crossing the blood brain barrier for brain targeting through oral delivery. To overcome this problem the various system such as: nasal spray, gels, emulsions, droplets, suspensions, powders and thermoreversible mucoadhesive gels etc have been studied for n...
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ژورنال
عنوان ژورنال: Molecules
سال: 2015
ISSN: 1420-3049
DOI: 10.3390/molecules20034124